This tune is thought to commemorate the successful May 1813 American repulsion of attacking British naval forces at Sackett's Harbor. Now named Sackets Harbor, the town is located at the eastern end of Lake Ontario in New York and was important in the buildup of the American fleet during the War of 1812.
This tune was written to commemorate the battle of Culloden Moor, Scotland. On the very bloody morning of April 16, 1746, 8,000 English troops massacred a Scottish army of 7,000, thus ending the Jacobite Rebellion in Scotland. Some sources instead give an Appalachian origin to this tune, but it seems likely the tune migrated with the Scots that settled the area. There are a number of other unrelated tunes with the same name.